News and Events
Congratulations to Zoe
Well done to Zoe, who has passed her first year viva! Zoe's work on LIVE-PAINT impressed the panel, and we are all excited about her future work! |
New super-resolution method for imaging in live cells
We have published a new approach to super-resolution imaging in live cells. Entitled "LIVE-PAINT", the method was developed in collaboration with Lynne Regan's lab in the School of Biology. LIVE-PAINT takes advantage of peptide-protein interactions; the protein-of-interest is tagged with a short peptide sequence, which has a binding partner fused to a fluorescence protein. As the fluorescent protein and peptide transiently bind, a fluorescent burst results, and this is accurately pinpointed with nanometre accuracy. Repeated binding events allow a super-resolution image to be built from this. Well done to Curran, Zoe, Louise, Owen and Simon! |
New paper in Nature Cell Death and Differentiation
A recent paper has been published in Cell Death and Differentiation on a mechanism of cell death caused by alpha-synuclein oligomers in Parkinson's disease. In a collaboration between the University of Edinburgh, UCL, The Crick Institute, the University of Aberdeen, the University of New York, and the University of Cambridge, the paper describes how oligomers lead to lipid peroxidation, which causes cell death via ferroptosis. |
Sarah's submission of her 5th year report
Huge congratulations to Sarah Aitken who submitted the dissertation on her work done throughout her final year at Edinburgh. Working with Mike Daniels in Barry McColl's lab, Sarah used single-molecule methods to characterise the aggregation of amyloid beta, and also looked at the response of immune cells to the toxic oligomers formed. |
Mathew presents his research to EASTBIO group
On the 1st May, Mathew presented the groups research to the EASTBIO World Class Underpinning Bioscience group. Due to the isolation rules relating to the COVID-19 Pandemic, this was done via teleconferencing, and so a recording of the presentation was also made. This is accessible on this website. |
Parkinson's UK Edinburgh Research Interest Group
Mathew recently presented the ESMB's work to the Parkinson's UK Edinburgh Research Interest Group. He was joined by Craig and Alex from the group, and also Kiani Jeacock from David Clarke's research group. The event was well-attended by those living with Parkinson's and their carers, and gave us the opportunity to talk about the strives we're making in understanding how protein aggregation occurs.
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PhD positions available in 2020
We have a number of PhD positions available in 2020. Check out Positions for more information. |
SULSA conference presentations
The group had an excellent time attending the SULSA conference in Edinburgh. Mathew gave a presentation on the group's recent work (which was faithfully recorded by Dr. Mathis Riehle from the University of Glasgow- see below), whilst Craig and Alex presented posters on their work on alpha-synuclein. |
Welcome to Katie, Zoë and Sarah
The Edinburgh single-molecule biophysics group is happy to welcome Katie, Zoë and Sarah. Katie has started her Ph.D. working with Mathew and Seth Grant on elucidating the structure of post-synaptic complexes, whilst Zoë's Ph.D. project is joint with Lynne Regan and focuses on developing a new super-resolution microscopy method. Sarah is a fifth year Chemistry student, and will be working on the peptides associated with Alzheimer's disease. |
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